
Оптиконейромиелит: клиническое наблюдение
Статья в журнале
Русский
Библиогр.: с. 21 (8 назв.)
616.832-002
оптиконейромиелит; рассеянный склероз; демиелинизация; антитела; аквапорин 4; магнитно-резонансная томография; амавроз; парапарез; моноклональные антитела; neuromyelitis optica; multiple sclerosis; demyelination; antibodies; anti-aquaporin-4 antibodies; magnetic resonance imaging; amavrosis; paraparesis; monoclonal antibodies; targent therapy
Медицина и здравоохранение / Клиническая медицина / Неврология
Вестник Северо-Восточного федерального университета им. М. К. Аммосова. – 2018. – N 3 (12)
C. 17-21
Вестник Северо-Восточного федерального университета им. М. К. Аммосова
Якутск, Северо-Восточный федеральный университет
2222-5404 (print)
РИНЦ 2017: 0,237
The problem of autoimmune diseases is relatively young, about 50 years, but despite the short period, it has become the most relevant in modern clinical neurology. A special place among the demyelinating autoimmune disease is neuromyelitis optica. Neuromyelitis optica the second most frequent form of inflammatory, autoimmune, demyelinating disease after multiple sclerosis. In the last decade, the scientific understanding of Devic’s disease has expanded significantly. Neuromyelitis optica refers to rare, demyelinating diseases of the nervous system, while in the literature there is no precise data on the incidence and prevalence of the disease. To date, information about epidemiology is based on the results of individual studies. It is known, that the disease is more often diagnosed among people of Asian descent, in all populations women are more often ill. Neuromyelitis optica, unlike other demyelinating diseases, has a severe progressive course and quickly leads to persistent disability. To date, with the isolation of a specific marker (NMO-IgG), there are opportunities for an accurate diagnosis. This article presents a case of a recurring course of opticoneuromyelitis meeting the known diagnostic criteria, including the determination of aquaporin-4 antibodies of aquaporin 4 in serum. Timely diagnosis of the disease, taking into account some clinical features, using immunological methods (determination of oligoclonal antibodies, determination of the level of aquaporin-4 antibodies), instrumental methods (especially MRI in neuromyelitis optica), timely adequate treatment, will help reduce the likelihood of irreversible neurological deficit
Оптиконейромиелит: клиническое наблюдение / Н. Ю. Горохова, Т. Я. Николаева, Т. Е. Попова, Л. Т. Оконешникова // Вестник Северо-Восточного федерального университета им. М. К. Аммосова. Серия: Медицинские науки.— 2018. — N 3 (12). — С. 17-21.
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